| Subject | Lead | Year | Title | Link | Type | Free |
| Causes |
Krishnappa V. |
2017 |
Atypical Hemolytic Uremic Syndrome: A Meta-Analysis of Case Reports Confirms the Prevalence of Genetic Mutations and the Shift of Treatment Regimens |
https://ahusallianceaction.org/wp-content/uploads/2017/12/Krishnappa_et_al-2017-Therapeutic_Apheresis_and_Dialysis.pdf |
Meta-analysis |
yes |
| Treatment |
Van de Walle |
2017 |
Improved renal recovery in patients with atypical hemolytic uremic syndrome following rapid initiation of eculizumab treatment. |
https://www.ncbi.nlm.nih.gov/pubmed/26995002 |
Case studies |
yes |
| Overview |
Yoshida |
2017 |
Atypical hemolytic uremic syndrome ( in Japan) |
https://rrtjournal.biomedcentral.com/articles/10.1186/s41100-016-0088-1 |
Summary |
yes |
| Trigger |
Raufi |
2016 |
Atypical Hemolytic Uremic Syndrome Secondary to Lupus Nephritis, Responsive to Eculizumab |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062623/ |
Case Studies |
yes |
| Diagnosis |
Barnard |
1965 |
THE HAEMOLYTIC-URAEMIC SYNDROME OF INFANCY |
http://journals.co.za/docserver/fulltext/CAJM/11/2/4480.pdf?expires=1503756566&id=id&accname=guest&checksum=2D3223C736894331E2F46DD4D3E73CA9 |
Case studies |
yes |
| Diagnosis |
Symmer |
1952 |
Thrombotic Microangiopathic Haemolytic Anaemia |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2021829/?page=1 |
Article |
yes |
| Treatment |
Cheong |
2016 |
Clinical Practice Guidelines for the Management of Atypical Hemolytic Uremic Syndrome in Korea |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4999392/ |
Guidelines |
yes |
| Extra Renal Involvement |
Hofer J |
2014 |
Extra-renal manifestations of complement-mediated thrombotic microangiopathies |
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157546/ |
Article |
yes |
| Extra Renal Involvement |
Ardissino G |
2013 |
Skin Involvement in Atypical Hemolytic Uremic Syndrome |
https://ahusallianceaction.org/wp-content/uploads/2017/05/Ardissino-et-al-AJKD-epub-SKIN.pdf |
pdf |
yes |
| Overview |
Noris |
2016 |
Genetic Atypical Hemolytic-Uremic Syndrome |
https://www.ncbi.nlm.nih.gov/books/NBK1367/ |
NCBI GeneReview |
yes |
| Registry |
Woodward |
2016 |
An innovative and collaborative partnership between patients with rare disease and industry-supported registries: the Global aHUS Registry |
http://ojrd.biomedcentral.com/articles/10.1186/s13023-016-0537-5 |
Article |
yes |
| Treatment |
Licht |
2015 |
Efficacy and safety of eculizumab in atypical hemolytic uremic syndrome from 2-year extensions of phase 2 studies. |
http://www.ncbi.nlm.nih.gov/pubmed/25651309 |
Study |
yes |
| Triggers |
Yasuda |
2016 |
Postoperative Atypical Hemolytic Uremic Syndrome Treated Successfully with Eculizumab. |
http://www.ncbi.nlm.nih.gov/pubmed/27150874 |
Case study |
yes |
| Triggers |
Thadjudeen |
2013 |
A case of atypical hemolytic uremic syndrome successfully treated with eculizumab. |
http://www.ncbi.nlm.nih.gov/pubmed/24570684 |
Case study |
yes |
| Treatment |
Fakouri |
2013 |
Atypical hemolytic uremic syndrome: from the rediscovery of complement to targeted therapy. |
http://www.ncbi.nlm.nih.gov/pubmed/23756030 |
Study |
no |
| Treatment |
Legendre |
2013 |
Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/23738544 |
Trial |
yes |
| Treatment |
Sheerin |
2016 |
A national specialized service in England for atypical haemolytic uraemic syndrome-the first year’s experience. |
http://www.ncbi.nlm.nih.gov/pubmed/25899302 |
Study |
no |
| Treatment |
Wong |
2015 |
Patient stratification and therapy in atypical haemolytic uraemic //www.ncbi.nlm.nih.gov/pubmed/26037115syndrome (aHUS). |
http://www.ncbi.nlm.nih.gov/pubmed/26037115 |
Study |
no |
| Treatment |
Wong |
2015 |
Anticomplement C5 therapy with eculizumab for the treatment of paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. |
https://www.ncbi.nlm.nih.gov/pubmed/25468487 |
Lit. |
no |
| Treatment |
Morgan |
2015 |
Complement, a target for therapy in inflammatory and degenerative diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/26493766 |
Lit. |
no |
| Treatment |
Kaplan |
2014 |
Current treatment of atypical hemolytic uremic syndrome |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204535/ |
Study |
yes |
| Treatment |
Richardo |
2014 |
Development of RA101348, a Potent Cyclic Peptide Inhibitor of C5 for Complement-Mediated Diseases |
http://www.bloodjournal.org/content/124/21/2936 |
Study |
yes |
| Treatment |
Scully |
2014 |
How I treat thrombotic thrombocytopenic purpura and atypical haemolytic uraemic syndrome |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163720/ |
Study |
yes |
| Treatment |
Westra |
2012 |
A new era in the diagnosis and treatment of atypical haemolytic uraemic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/22516576 |
Study |
no |
| Treatment |
Risitano |
2011 |
Design and development of TT30, a novel C3d-targeted C3/C5 convertase inhibitor for treatment of human complement alternative pathway–mediated diseases |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3208285/ |
Study |
yes |
| Transplant |
Xie |
|
Tailored eculizumab therapy in the management of complement factor H-mediated atypical hemolytic uremic syndrome in an adult kidney transplant recipient: a case report. |
http://www.ncbi.nlm.nih.gov/pubmed/23195022 |
Case study |
no |
| Transplant |
Okumi |
2016 |
Prevention and treatment of atypical hemolytic uremic syndrome after kidney transplantation. |
http://www.ncbi.nlm.nih.gov/pubmed/26988663 |
Study |
no |
| Transplant |
Zuber |
2012 |
Eculizumab for atypical hemolytic uremic syndrome recurrence in renal transplantation. |
http://www.ncbi.nlm.nih.gov/pubmed/22958221 |
Trial |
yes |
| Secondary aHUS |
de Fontbrun |
2015 |
Use of Eculizumab in Patients With Allogeneic Stem Cell Transplant-Associated Thrombotic Microangiopathy: A Study From the SFGM-TC. |
http://www.ncbi.nlm.nih.gov/pubmed/25651309 |
Case study |
no |
| Secondary aHUS |
Jodele |
2016 |
Variable Eculizumab Clearance Requires Pharmacodynamic Monitoring to OptimizeTherapy for Thrombotic Microangiopathy after Hematopoietic Stem Cell Transplantation. |
http://www.ncbi.nlm.nih.gov/pubmed/26456258 |
Study |
no |
| Secondary aHUS |
Jodele |
2016 |
The genetic fingerprint of susceptibility for transplant-associated thrombotic microangiopathy. |
http://www.ncbi.nlm.nih.gov/pubmed/26603840 |
Study |
no |
| Secondary aHUS |
Li |
2015 |
Clinical characteristics of hemolytic uremic syndrome secondary to cobalamin C disorder in Chinese children. |
http://www.ncbi.nlm.nih.gov/pubmed/26253414 |
Case study |
no |
| Secondary aHUS |
Cornec le Gall |
2014 |
Adult-onset eculizumab-resistant hemolytic uremic syndrome associated with cobalamin C deficiency. |
http://www.ncbi.nlm.nih.gov/pubmed/24210589 |
Case study |
no |
| Secondary aHUS |
Shiari |
2014 |
Atypical hemolytic-uremic syndrome associated with antiphospholipid antibodies and antiphospholipid syndrome; a novel presentation |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4191725/ |
Case study |
no |
| Secondary aHUS |
Menni |
2012 |
Neonatal atypical hemolytic uremic syndrome due to methylmalonic aciduria and homocystinuria. |
http://www.ncbi.nlm.nih.gov/pubmed/22447314 |
Case study |
no |
| Secondary aHUS |
Hale |
2005 |
Hemolytic uremic syndrome after bone marrow transplantation: clinical characteristics and outcome in children. |
http://www.ncbi.nlm.nih.gov/pubmed/16275594 |
Study |
yes |
| Secondary aHUS |
Jodele |
2014 |
Eculizumab therapy in children with severe hematopoietic stem cell transplantation-associated thrombotic microangiopathy. |
http://www.ncbi.nlm.nih.gov/pubmed/24370861/ |
Case study |
yes |
| Registry |
Licht |
2015 |
The global aHUS registry: methodology and initial patient characteristics. |
https://www.ncbi.nlm.nih.gov/pubmed/26654630?dopt=Abstract |
Study |
yes |
| Pregnancy |
Fakouri |
2016 |
Pregnancy-related thrombotic microangiopathies: Clues from complement biology. |
http://www.ncbi.nlm.nih.gov/pubmed/27158062 |
Study |
no |
| Pregnancy |
Thomas |
2016 |
How we manage thrombotic microangiopathies in pregnancy. |
http://www.ncbi.nlm.nih.gov/pubmed/27019232 |
Study |
no |
| Pregnancy |
Goodship |
2010 |
Pulling the Trigger in Atypical Hemolytic Uremic Syndrome: The Role of Pregnancy |
http://jasn.asnjournals.org/content/21/5/731.full |
Study |
yes |
| Pregancy |
Fakouri |
2010 |
Pregnancy-Associated Hemolytic Uremic Syndrome Revisited in the Era of Complement Gene Mutations |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2865741/ |
Study |
yes |
| Genetic Causes |
Warwicker |
1998 |
Genetic studies into inherited and sporadic hemolytic uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/9551389 |
Study |
yes |
| Eculizumab |
Pereira Palma |
2016 |
Critical appraisal of eculizumab for atypical hemolytic uremic syndrome |
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4835139/ |
Study |
yes |
| Eculizumab |
Greenbaum |
2016 |
Eculizumab is a safe and effective treatment in pediatric patients with atypical hemolytic uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/26880462 |
Trial |
yes |
| Eculizumab |
Fakouri |
2014 |
Insights from the use in clinical practice of eculizumab in adult patients with atypical hemolytic uremic syndrome affecting the native kidneys: an analysis of 19 cases. |
http://www.ncbi.nlm.nih.gov/pubmed/24021908 |
Study |
yes |
| Diagnosis |
Akesson |
2016 |
Indications of underdiagnosis of Atypical Hemolytic Uremic Syndrome in a cohort referred to the Coagulation Unit in Malmo, Sweden, for analysis of ADAMTS13 2007-2012. |
http://www.ncbi.nlm.nih.gov/pubmed/27175932 |
Study |
no |
| Causes |
Miyata |
2016 |
No association between dysplasminogenemia with p.Ala620Thr mutation and atypical hemolytic uremic syndrome |
http://www.ncbi.nlm.nih.gov/pubmed/27194432 |
Study |
no |
| Causes |
Rigothier |
2015 |
Distal Angiopathy and Atypical Hemolytic Uremic Syndrome: Clinical and Functional Properties of an Anti-Factor H IgAλ Antibody. |
http://www.ncbi.nlm.nih.gov/pubmed/26015278 |
Case study |
no |
| Causes |
Norris |
2015 |
Podocyte dysfunction in atypical haemolytic uraemic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/25599621 |
Study |
no |
| Causes |
Mele |
2015 |
Characterization of a New DGKE Intronic Mutation in Genetically Unsolved Cases of Familial Atypical Hemolytic Uremic Syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/25854283 |
Case study |
no |
| Causes |
Bernabeu-Herroro |
2015 |
Complement factor H, FHR-3 and FHR-1 variants associate in an extended haplotype conferring increased risk of atypical hemolytic uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/26163426 |
Study |
no |
| Causes |
Diamante Chiodini |
2014 |
Eculizumab in anti-factor h antibodies associated with atypical hemolytic uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/24843055 |
Case study |
no |
| Causes |
Westland |
2014 |
Phenotypic expansion of DGKE-associated diseases. |
http://www.ncbi.nlm.nih.gov/pubmed/24511134 |
Case study |
yes |
| Causes |
Sansbury |
2014 |
Factors determining penetrance in familial atypical haemolytic uraemic syndrome |
http://www.ncbi.nlm.nih.gov/pubmed/25261570 |
Study |
no |
| Causes |
Bu |
2014 |
Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. |
http://www.ncbi.nlm.nih.gov/pubmed/24029428 |
Study |
no |
| Causes |
Rodriguez de Cordoba |
2014 |
Genetics of atypical hemolytic uremic syndrome (aHUS) |
http://www.ncbi.nlm.nih.gov/pubmed/24799305 |
Study |
no |
| Causes |
Meri |
2013 |
Complement activation in diseases presenting with thrombotic microangiopathy. |
http://www.ncbi.nlm.nih.gov/pubmed/23743117 |
Study |
no |
| Causes |
Fremeaux- Baachi |
2013 |
Pathophysiology of atypical hemolytic uremic syndrome. Ten years of progress, from laboratory to patient]. |
http://www.ncbi.nlm.nih.gov/pubmed/24594571 |
Study |
no |
| Causes |
Dragon-Durey |
2010 |
Clinical features of anti-factor H autoantibody-associated hemolytic uremic syndrome |
http://www.ncbi.nlm.nih.gov/pubmed/21051740 |
Study |
yes |
| Causes |
Gasser |
1955 |
[Hemolytic-uremic syndrome: bilateral necrosis of the renal cortex in acute acquired hemolytic anemia]. |
http://www.ncbi.nlm.nih.gov/pubmed/13274004 |
Case study |
no |
