Try the ChristmaHUS Quiz and when you finish join in with the aHUS Christmas Carol.
Here’s a 20-question multiple-choice quiz on aHUS. Each question has one correct answer and three distractors. Answers at the end make a note of the letter.
1. What does “aHUS” stand for?
A. Acute Hepatic-Uremic Syndrome
B. Atypical Hemolytic Uremic Syndrome
C. Autoimmune Hematological Unusual Syndrome
D. Acquired Hepatic-Uremic Syndrome
2. What is aHUS primarily caused by?
A. Bacterial infection
B. Complement system dysregulation
C. Viral infection
D. Autoimmune antibody destruction
3. Which organ is primarily affected in aHUS?
A. Liver
B. Brain
C. Kidneys
D. Lungs
4. Which symptom is commonly associated with aHUS?
A. Persistent cough
B. Severe diarrhea
C. Thrombocytopenia
D. Enlarged spleen
5. Which component of the immune system is dysregulated in aHUS?
A. T-cell response
B. Complement pathway
C. Cytokine production
D. Antibody-mediated immunity
6. What is the most common genetic abnormality associated with aHUS?
A. Mutation in CFH (Complement Factor H)
B. Mutation in hemoglobin gene
C. Mutation in fibrinogen gene
D. Mutation in CFTR (Cystic Fibrosis Transmembrane Regulator)
7. What is the role of complement inhibitors in treating aHUS?
A. Stimulate platelet production
B. Suppress T-cell activity
C. Block overactivation of the complement system
D. Enhance kidney function directly
8. What is the hallmark triad of clinical features in aHUS?
A. Hemolytic anemia, thrombocytopenia, and kidney failure
B. Anemia, fever, and joint pain
C. Hypertension, diabetes, and proteinuria
D. Proteinuria, haematuria, and edaema
9. How is aHUS typically distinguished from other forms of HUS?
A. Absence of diarrhea
B. Presence of fever
C. Severe lung involvement
D. Elevated blood glucose levels
10. Which of the following lab findings is most consistent with aHUS?
A. Low white blood cell count
B. High platelet count
C. Schistocytes on blood smear
D. Normal hemoglobin levels
11. What is the role of plasma exchange in aHUS management?
A. Cure the disease permanently
B. Remove autoantibodies or mutated proteins
C. Reduce blood pressure
D. Stimulate red blood cell production
12. Which medication is commonly used as a complement inhibitor in aHUS?
A. Eculizumab
B. Aspirin
C. Warfarin
D. Prednisone
13. What complication is a patient with untreated aHUS most at risk for?
A. Chronic obstructive pulmonary disease
B. Permanent kidney failure
C. Diabetes mellitus
D. Severe allergic reactions
14. What triggers aHUS episodes in some individuals?
A. Pregnancy, infection, or certain medications
B. High cholesterol and obesity
C. Smoking and alcohol consumption
D. Exposure to allergens
15. What is the inheritance pattern of genetic predisposition to aHUS?
A. Autosomal dominant or recessive
B. X-linked recessive
C. Mitochondrial inheritance
D. Y-linked inheritance
16. Which diagnostic test is most useful for confirming complement dysregulation in aHUS?
A. Complement panel (C3, C4 levels)
B. Complete blood count (CBC)
C. Blood glucose test
D. Liver function test
17. What is the role of genetic testing in aHUS?
A. Identify specific complement mutations
B. Diagnose viral infections
C. Detect blood clotting disorders
D. Measure kidney function
18. Which population is at risk for developing aHUS?
A. Infants and young children only
B. Adults only
C. All age groups
D. Post-menopausal women only
19. How does aHUS differ from TTP (Thrombotic Thrombocytopenic Purpura)?
A. aHUS involves ADAMTS13 deficiency
B. TTP is caused by complement dysregulation
C. aHUS does not have severe neurological symptoms
D. TTP is exclusively genetic
20. What is a key long-term management strategy for aHUS?
A. Annual vaccinations
B. Regular monitoring and complement inhibitor therapy
C. High-dose steroids indefinitely
D. Low-sodium diet
ANSWERS BELOW
| Question | Answer |
| 1 | B |
| 2 | B |
| 3 | C |
| 4 | C |
| 5 | B |
| 6 | A |
| 7 | C |
| 8 | A |
| 9 | A |
| 10 | C |
| 11 | B |
| 12 | A |
| 13 | B |
| 14 | A |
| 15 | A |
| 16 | A |
| 17 | A |
| 18 | C |
| 19 | C |
| 20 | B |
It’s ChristmaHUS and time to sing the aHUS carol sung to “ Bleak mid winter” or “;Simply having a wonderful Christmas time” as you wish🙂
” ALL’S ALRIGHT
[Verse 1]
Snow is falling, bells are rung ,
The air is filled with carols sung
But for some, this time of year
Is filled with dread but have no fear
[Chorus]
aHUS is a rare disease
Harms the kidneys, until they cease
Don’t give up, keep up the fight
And carry on ’til all’s alright
[Verse 2]
The holiday’s a time of cheer
For some with aHUS, it’s hard to hear
The laughter and joy abound
In bleak mid winter’s frozen ground
[Chorus] aHUS is a rare disease
Harms the kidneys until they cease
Don’t give up, follow the light
And carry on ’til all’s alright
(Verse 3)
Snowflakes fall, whisper a prayer
For families united in a harmony of care
in winter’s chill , warmth in their song
Tells that hope and love is strong.
[Bridge] Raise awareness, spread the word
So round the world, their voice is heard
Never give up, nor back down
Keep right on ’til health is found
[Chorus] aHUS is a rare disease
Harms the kidneys until they cease
This time of year, don’t lose sight
Of happier times when all’s alright“
Article No 704
